A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75Article Published on 2023-01-312023-07-11 Journal: Cell Reports [Category] COVID19(2023년), [키워드] ACE2 receptor antigenic variation BA.2.75 COVID-19 CP: Immunology CP: Microbiology Immune escape RBD SARS-CoV-2 spike variant Variant of concern. [DOI] 10.1016/j.celrep.2022.111903 PMC 바로가기
SARS-CoV-2 Anti-Spike IgG Antibody and ACE2 Receptor Binding Inhibition Levels among Breakthrough Stage Veteran PatientsArticle Published on 2022-12-212023-07-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), [키워드] ACE2 receptor antibody assay Breakthrough infection COVID-19 immunization SARS-CoV-2 Serology. [DOI] 10.1128/spectrum.02747-22 PMC 바로가기
Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell EntryArticle Published on 2022-12-212023-07-10 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] ACE2 receptor endocytosis SARS-CoV-2 two-pore channel type 2 zebrafish. [DOI] 10.1128/jvi.01418-22 PMC 바로가기
Omicron BA.1 and BA.2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2Article Published on 2022-12-012022-11-16 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 receptor Affect angiotensin-converting enzyme 2 Area B.1.1.529 binding binding efficiency binding free energy conformation domain dominant explicit full-length glycans glycoprotein host cells hydrophobic interaction infect Infection initiated Interaction interactions ions Mechanics MMPBSA molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated Mutation omicron Omicron variant performed RBD RBD-ACE2 receptor residue Salt Bridge SARS-CoV-2 SARS-CoV-2 spike glycoprotein Simulation spike spike glycoprotein spike glycoprotein. strain surface the receptor-binding domain trajectory variant variant of SARS-CoV-2 variants wild-type [DOI] 10.1016/j.jmgm.2022.108286 PMC 바로가기
The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors. robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
SARS-CoV-2 cell entry beyond the ACE2 receptorArticle Published on 2022-11-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor AGTR2 ASGR1 Asymptomatic auxiliary B.1.1.529 B.1.1.7 B.1.617.1 B.1.617.2 binding carried CD147 CD26 cell entry cell surface receptors CLEC4G Cochrane Library COVID19 Delta Delta+ develop English enzyme erythrocyte Evidence explain facilitate host cell Hypoxemia Infection KREMEN1 LDLRAD3 membrane protein MeSH term neuropilin omicron organs Protein receptor receptors S protein SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2. SARSCoV-2 selected target therapeutic agent tissue tropism TMEM30A Transmission variants of SARS-CoV-2 viral entry virus entry [DOI] 10.1007/s11033-022-07700-x PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motifArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 receptor acute respiratory syndrome antibody Beta binding conserved coronavirus cryo-EM structure Delta delta variant demonstrated develop DNA epitope Evolution glycosylation site identify immune lung mice neutralize neutralizing activities omicron RBD Receptor binding domain receptor binding motif reduced SARS coronavirus SARS coronaviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-specific B cell sequenced single-cell the RBD therapeutic variant Viral load viral spike protein were infected [DOI] 10.1126/sciimmunol.abp9962 PMC 바로가기